One of the many new features added in ANA 2 Ultra Edition is the ability to switch skins when presets are changed. Depending on the bank of presets you're choosing from (eg. Ultra EuroRack Ultra SD-1, etc) , the skin will be changed to that skin.
By default, this setting is disabled. It can be enabled by clicking the Settings wheel and checking the "USE PRESET SKINS?" option. Please see the following GIF:
Note: You'll notice a 1-2 second delay when switching to a preset with a new skin. Audio will stop during the switch.